Figure 2. Elimination of senescent SC in aged and chronically denervated nerves alters cytokine profiling in vivo .

1. Expression analysis of 111 different cytokines in the context of aging or chronic denervation. Comparison between adult chronic denervation (Adult Chr‐D) or acute denervation in aged mice (Aged Acu‐D).
2. Fold change comparison of 111 different cytokines in the context of chronic denervation in adults and acute denervation in aged mice and after ABT‐263 treatment. Comparison between adult mice after Chr‐D and aged mice after Acu‐D in the context of ABT‐263 treatment, vehicle treatment, and compared to adult Acu‐D regenerative response.
3. Expression analysis of 25 different cytokines in the context of aging or chronic denervation. Comparison between Chr‐D in adults or Acu‐D in aging conditions, in mice treated with vehicle or ABT‐263 compared to adult Acu‐D regenerative response. Data are expressed as mean density (N = 3 animals per group, *P < 0.05 by Student's t‐test compared between conditions; error bars indicate SEM).

Source data are available online for this figure.