Table 3. C Statistics and 95% CIs for Each Model and Number of Observations and Atherosclerotic Cardiovascular Disease (ASCVD) Events, by Race and Sex Strata^a.

Model	C statistic (95% CI)
	Black		White
	Female	Male	Female	Male
Observations by each race and sex stratum
No. of participants/No. of ASCVD events	2934/166	1709/153	3830/195	3165/297
Model A: original pooled cohort risk equationb	0.69 (0.66-0.73)	0.66 (0.61-0.70)	0.75 (0.72-0.79)	0.66 (0.63-0.69)
Model B: original pooled cohort risk equation with REGARDS-specific coefficientsc	0.71 (0.68-0.75)	0.69 (0.64-0.73)	0.77 (0.74-0.81)	0.68 (0.64-0.71)
Model C: simplified REGARDS-specific pooled cohort risk equationc	0.71 (0.68-0.75)	0.68 (0.64-0.73)	0.77 (0.74-0.80)	0.68 (0.65-0.71)
Model D: model C without raced	0.71 (0.67-0.75)	0.68 (0.63-0.72)	0.76 (0.73-0.80)	0.68 (0.65-0.71)
Model E: model D plus SDOH variablese	0.72 (0.68-0.76)	0.68 (0.64-0.72)	0.77 (0.74-0.80)	0.68 (0.65-0.71)

Abbreviations: REGARDS, Reasons for Geographic and Racial Differences in Stroke; SDOH, social determinants of health.

^a All models employed the entire study population (n = 11 138) with imputation for missing values.

^b Defined in Goff et al.⁷

^c Simplified Pooled Cohort Risk Equation includes age, high-density lipoprotein, systolic blood pressure interaction with treatment, current smoking status, and diabetes status.

^d Model fitted on each sex stratum (male and female) and C statistics and associated 95% CIs were computed for each race stratum using bootstrapping.

^e The following SDOH variables were included in this model: Area Deprivation Index (continuous variable), low education, low income, zip code in poverty, no insurance, health professional shortage area category (indicator variables as defined in Table 1 and 2).