Fig. 3.

Subtype progression patterns identified by the SuStaIn algorithm. a W-scores of subtype progression patterns for each region for each subtype. Color shade represents the probability that w-score in each region is reached at each SuStaIn stage, with red for mild atrophy (w-score = 1), magenta for moderate atrophy (w-score = 2), and blue for severe atrophy (w-score = 3). b Spatial distribution and degree of cortical atrophy at each SuStaIn stage. Color shade represents the cumulative sum of probabilities in each brain region