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Progression of SuStaIn subtypes. a Distribution of individuals assigned to each SuStaIn stage in different clinical phenotypes. b–e Comparison of SuStaIn stages between different clinical phenotypes (b), King’s stages (c), genetic pathogenic variants (d), and TDP-43 types (e). f–h Increasing SuStaIn stage was correlated with longer disease duration (f), longer diagnostic delay (g) and worse cognitive function (h) across all subtypes. *P < 0.05, **P < 0.01, ****P < 0.0001, ****P < 0.0001
