TABLE 1.
Unique designations of opa alleles and their variable regions
| opa allelea | Speciesb | Clusterc | GenBank accession no. | Designationd
|
||
|---|---|---|---|---|---|---|
| SV | HV1 | HV2 | ||||
| 41 | Nm C C1938 | Nm-1 | X06445 | 109 | 35 | 37 |
| 46 | Ng JS3 | Ng-3 | X12625 | 113 | 82 | 83 |
| 47 | Ng MS11 | Ng-3 | X60709 | 130 | 77 | 78 |
| 49 | Ng MS11 | Ng-1 | X60711 | 127 | 52 | 53 |
| 65 | Ng VP1 | Ng-2 | Z18940 | 116 | 94 | 95 |
| 66 | Ng VP1 | Ng-1 | Z18941 | 126 | 55 | 56 |
| 67 | Ng VP1 | Ng-1 | Z18942 | 119 | 88 | 89 |
| 68 | Ng VP1 | Ng-1 | Z18936 | 126 | 55 | 57 |
| 69 | Ng F62-SF | Ng-3 | X15780 | 122 | 80 | 81 |
| 70 | Ng MS11 | Ng-1 | X52373 | 117 | 73 | 74 |
| 71 | Ng MS11 | Ng-1 | X52370 | 127 | 58 | 59 |
| 74 | Ng MS11 | Ng-1 | X52368 | 123 | 73 | 74 |
| 75 | Ng MS11 | Ng-2 | X52367 | 124 | 75 | 76 |
| 77 | Ng MS11 | Ng-3 | X52365 | 123 | 84 | 85 |
| 78 | Ng MS11 | Ng-1 | X52371 | 128 | 68 | 69 |
| 79 | Ng MS11 | Ng-1 | X52364 | 120 | 71 | 96 |
| 87 | Ns | Outgroup | U12287 | 132 | 90 | 91 |
| 88 | Nf | Outgroup | U12288 | 131 | 92 | 93 |
| 92 | Nm A | Nm-1 | AF001199 | 101 | 5 | 6 |
| 93 | Nm A | Nm-1 | AF001200 | 102 | 5 | 6 |
| 94 | Nm A | Nm-1 | AF001201 | 100 | 7 | 8 |
| 99 | Nm A | Nm-2 | AF001181 | 100 | 1 | 2 |
| 100 | Nm A | Nm-1 | AF001195 | 100 | 9 | 10 |
| 101 | Nm A | Nm-2 | AF001179 | 109 | 3 | 4 |
| 102 | Nm A | Nm-1 | AF001204 | 103 | 24 | 25 |
| 118 | Nm A | Nm-1 | AF001186 | 103 | 13 | 14 |
| 123 | Nm B 188/87 | Nm-1 | AF016290 | 100 | 38 | 19 |
| 124 | Nm B 188/87 | Nm-1 | AF016288 | 111 | 39 | 40 |
| 126 | Nm B 188/87 | Nm-2 | AF016292 | 106 | 41 | 42 |
| 127 | Nm B 190/87 | Nm-1 | AF016286 | 100 | 43 | 44 |
| 128 | Nm B190/87 | Nm-1 | AF016289 | 106 | 45 | 46 |
| 129 | Nm B190/87 | Nm-1 | AF016285 | 100 | 43 | 48 |
| 130 | Nm B190/87 | Nm-1 | AF016291 | 107 | 49 | 50 |
| 131 | Nm A | Nm-1 | AF001194 | 100 | 9 | 10 |
| 132 | Nm A | Nm-2 | AF001180 | 100 | 1 | 2 |
| 133 | Nm A | Nm-1 | AF001185 | 103 | 13 | 14 |
| 134 | Nm A | Nm-1 | AF001193 | 100 | 15 | 51 |
| 540 | Nm C FAM18 | Nm-1 | X63110 | 103 | 30 | 31 |
| 709 | Ng FA1090 | Ng-2 | X06436 | 118 | 63 | 67 |
| 900 | Nm C FAM18 | Nm-1 | X63111 | 103 | 32 | 97 |
| 1100 | Ng FA1090 | Ng-2 | X06435 | 115 | 63 | 64 |
| 1800 | Nm C FAM18 | Nm-1 | X63109 | 133 | 33 | 98 |
| 5100 | Nm C Z4197 | Nm-1 | U37256 | 109 | 28 | 540 |
| 5200 | Nm C Z4197 | Nm-2 | U37257 | 103 | 22 | 23 |
| 15063 | Ng MS11A | Ng-1 | U13708 | 121 | 61 | 62 |
Unique designation for each allele. Opa proteins implicated in invasion: Opa68, Opa71 (formerly called Opa50) (20), and Opa15063 (43).
Nm, N. meningitidis; Ng, N. gonorrhoeae; Ns, N. sicca; Nf, N. flava. Strain designations are included for N. gonorrhoeae and N. meningitidis serogroup B and C (17) strains. The serogroup B strains 188/87 and 190/87 were isolated in Norway and belong to the ET-5 complex; the serogroup C strains FAM18 and Z4197 are ET-37 complex strains isolated in the USA and Mali, respectively. The serogroup A strains were of subgroups III and IV-1 (25).
Cluster within tree in Fig. 3.
Unique designation based on nucleotide sequence. The amino acid sequences of SV103 and SV106 are identical, whereas the nucleotide sequences differ by 1 bp. These sequences are shown in Fig. 2 as SV-103. The amino acid sequences of HV1-13 and HV1-22 are identical, whereas the nucleotide sequences differ by 1 bp. These sequences are shown in Fig. 2 as HV1-13.