Table 5. Derivatization of 3-Benzyl-benzo[4,5]imidazo[2,1-b]thiazoles^a,b.

^aReaction conditions: Pd(OAc)₂ (0.015 mmol, 0.075 equiv), PPh₃ (0.03 mmol, 0.15 equiv), c (0.2 mmol, 1.0 equiv), e (0.3 mmol, 1.5 equiv), and Cs₂CO₃ (0.4 mmol, 2.0 equiv) in p-xylene (2.0 mL) at 135 °C under the N₂ atmosphere for 24 h.

^bIsolated yield after flash chromatography based on c.

^cBromobenzene was used.

^dA mixture of 17f and 18f was obtained (the isomeric ratio was approximately determined by ¹H NMR).