Table 10.
Influence of nicotine on phagocytosis.
| Effect = ↓ ↑ |
Assay | Exposure time | Tested concentration [mmol/l] |
Effective concentration [mmol/l] |
IC50/EC50 [mmol/l] |
Level of significance (P-value) |
Number of exp. |
Authors |
|---|---|---|---|---|---|---|---|---|
| Uptake bacteria = | uptake of 3H-thymididine-labeled F. nucleatum | 10/20/30/60min | 6.2 ✦ | − | − | − | 2 | Pabst et al., 1995 (63) |
| Uptake of microsphere ↓ | flow cytometry | 60min | 0.1 - 1 | 1 | − | < 0.001 | 4 | Ryder et al., 1994 (65) |
| Uptake bacteria ↓ | phase-contrast microscopy | 15min | 0.005 - 1.5 | 0.5 - 1.5 | − | < 0.001 | 3 | Seow et al., 1994 (64) |
| Uptake IgG-SRBC, C5a-stimulated ↓ | flow cytometry | 20min | 0.00001 - 0.001 | 0.001 | − | < 0.05 | 3-6 | Vukelic et al., 2013 (19) |
= no effect; ↓ effect on neutrophils inhibited by nicotine; ↑ effect on neutrophils strengthened by nicotine. ✦ Nicotine concentrations declared by the author.