Table 4.
Influence of nicotine on chemotaxis.
| Effect = ↓ ↑ |
Assay | Exposure time | Tested concentration [mmol/l] |
Effective concentration [mmol/l] |
IC50/EC50 [mmol/l] |
Level of significance (P-value) |
Number of exp. |
Authors |
|---|---|---|---|---|---|---|---|---|
| towards fMLP = | traversing agarose | 2h during movement | 0.0001 - 0.1 | − | – | n.d. | 2 - 4 | Gala et al., 1984 (75) |
| towards fMLP ↑ | traversing agarose | 90min preincubation | 0.0001 - 0.01 | 0.0001 - 0.01 | − | 0.0001 mmol/l: < 0.05 0.001 - 0.1mmol/l: < 0.01 |
5 | Nowak et al., 1990 (68) |
| towards fMLP ↓ | traversing agarose | 90min preincubation | 0.1 - 10 | 10 | − | < 0.01 | 5 | Nowak et al., 1990 (68) |
| towards fMLP ↑ | microchemotaxis chambers | 24h preincubation | 0.001 | 0.001 | − | < 0.01 | 5 | Aoshiba et al., 1996 (62) |
| towards fMLP ↑ | modified Boyden Chamber | n.s. | 0.00003 - 0.0308 | 0.00031 - 0.0308 | − | < 0.001 | 15 | Totti et al., 1984 (73) |
| towards fMLP ↑ | modified Boyden Chamber | n.s. | 0.0308 | 0.0308 | − | < 0.01 | 15 | Totti et al., 1984 (73) |
| towards fMLP = | modified Boyden Chamber | 45min during movement | 0.005 - 0.5 | − | − | − | 5 | Sasagawa et al., 1985 (72) |
| towards fMLP ↓ | traversing agarose | 15min preincubation + 2h during movement | 0.005 - 1.5 | 1 - 1.5 | − | < 0.001 | 3 | Seow et al., 1994 (64) |
| towards C5fr ↑ | modified Boyden Chamber | n.s. | 0.00003 - 0.0308 | 0.00031 - 0.0308 | − | < 0.001 | 15 | Totti et al., 1984 (73) |
| towards ZAS ↑ | traversing agarose | 90min preincubation | 0.0001 - 0.01 | 0.0001 - 0.01 | − | 0.0001 mmol/l: < 0.05 0.001 mmol/l: < 0.01 0.01 mmol/l: < 0.05 |
5 | Nowak et al., 1990 (68) |
| towards ZAS ↓ | traversing agarose | 90min preincubation | 0.1 - 10 | 1 - 10 | − | < 0.01 | 5 | Nowak et al., 1990 (68) |
| toward LTB4 ↓ | traversing agarose | 15min preincubation + 2h during movement | 0.005 - 1.5 | 1 - 1.5 | − | < 0.001 | 3 | Seow et al., 1994 (64) |
| towards CXCL8 ↓ | traversing agarose | 15min preincubation + 2h during movement | 0.005 - 1.5 | 1 - 1.5 | − | < 0.001 | 3 | Seow et al., 1994 (64) |
| toward CaAS ↓ | traversing agarose | 15min preincubation + 2h during movement | 0.005 - 1.5 | 1 - 1.5 | − | < 0.001 | 3 | Seow et al., 1994 (64) |
| towards EAS ↓ | modified Boyden Chamber | 2h during movement | 2 - 10 | 6 - 10 | IC50 = 3.5 | < 0.05 | 3 - 6 | Bridges et al., 1977 (76) |
| towards nicotine (↑) | traversing agarose | 90min | 0.0001 - 10 | (0.0001-10) | − | n.d. | 9 | Nowak et al., 1990 (68) |
= no effect; ↓ effect on neutrophils inhibited by nicotine; ↑ effect on neutrophils strengthened by nicotine. n.d., not determined; n.s., not stated.