Table 3.

Multivariate Cox analysis of survival

	HR	95% CI	P	HR	95% CI	P-value
Sex (male/female)	0.779	0.553–1.099	0.779
Age	0.983	0.964–1.002	0.072
Tumor diameter	1.443	1.308–1.592	<0.001	1.125	1.004–1.260	0.043
Differentiation	0.954	0.673–1.354	0.794
TNM stage	2.801	2.342–3.350	<0.001	2.211	1.778–2.749	<0.001
Histology (SCC/AC)	0.847	0.599–1.196	0.345
SFRP1(−/+)	4.874	3.395–6.995	<0.001	2.219	1.471–3.346	<0.001
PRKCB(−/+)	3.660	2.539–5.278	<0.001	2.093	1.446–3.030	<0.001

AC, adenocarcinoma; CI, confidence interval; HR, hazard ratio; SCC, squamous-cell carcinoma.