Table 2.

Differences in the main variables of interest for the total sample, over time.

Variable		T1 (n = 73)	T2 (n = 68)	T3 (n = 60)	T2–T1 (n = 68)	T3–T2 (n = 60)	T3–T1 (n = 60)	Graphic representation
Anxiety	Mean (SD)	3.1 (1.81)	2.9 (1.73)	2.2 (1.89)	−0.3 (1.82)	−0.7 (1.41)	−1.0 (1.89)
	$\beta$				−0.10	−0.26	−0.36
	p				0.261	0.008**	<.001***
Depression	Mean (SD)	1.4 (1.40)	1.3 (1.37)	0.9 (1.36)	−0.1 (1.36)	−0.3 (1.40)	−0.5 (1.78)
	$\beta$				−0.04	−0.33	−0.38
	p				0.771	0.053^	0.027*
QoL
Disease-related	Mean (SD)	15.7 (3.05)	17.4 (2.71)	19.3 (3.65)	1.8 (3.69)	1.9 (3.06)	3.7 (4.2)
	$\beta$				0.32	0.72	1.04
	p				0.003**	<.001***	<.001***
Physical	Mean (SD)	2.8 (0.84)	3.2 (0.73)	3.3 (0.86)	0.4 (0.90)	0.1 (0.76)	0.5 (0.90)
	$\beta$				0.41	0.14	0.55
	p				<.001***	0.242	<.001***
Mental	Mean (SD)	3.9 (0.90)	4.2 (0.74)	4.4 (0.85)	0.3 (1.01)	0.01 (0.88)	0.3 (1.07)
	$\beta$				0.27	0.07	0.34
	p				0.064^	0.647	0.026*
WIQ
WIQ distance	Mean (SD)	28.8 (26.72)	69.0 (31.79)	70.4 (35.57)	39.1 (37.97)	−3.3 (31.62)	41.5 (35.23)
	$\beta$				1.41	0.38	1.79
	p				<.001***	0.065^	<.001***
WIQ speed	Mean (SD)	20.8 (13.56)	38.7 (18.16)	40.7 (25.68)	17.6 (20.11)	−0.3 (25.02)	20.1 (26.08)
	$\beta$				0.89	0.21	1.10
	p				<.001***	0.191	<.001***
WIQ stairs	Mean (SD)	40.4 (32.97)	58.0 (37.01)	71.2 (34.33)	16.9 (50.76)	10.6 (40.27)	29.9 (45.24)
	$\beta$				0.86	0.48	1.34
	p				<.001***	0.035*	<.001***
Treadmill walking
PFWD	Mean (SD)	122.1 (93.40)	273.6 (160.28)	307.9 (202.16)	151.1 (146.87)	27.1 (152.65)	183.6 (185.46)
	$\beta$				151.34	31.50	182.84
	p				<.001***	0.132	<.001***
FWD	Mean (SD)	188.6 (120.97)	363.7 (174.32)	399.6 (210.97)	175.2 (157.44)	24.2 (158.70)	206.6 (173.34)
	$\beta$				175.17	30.26	205.43
	p				<.001***	0.154	<.001***
MWD	Mean (SD)	301.0 (139.23)	478.4 (227.37)	540.0 (277.37)	177.1 (192.52)	35.0 (171.60)	228.5 (222.08)
	$\beta$				0.84	0.51	1.35
	p				<.001***	<.001***	<.001***
6-minute walking
6MWD	Mean (SD)	329.5 (77.95)	363.6 (78.52)	378.5 (78.40)	30.8 (58.69)	7.9 (53.87)	42.8 (61.21)
	$\beta$				31.72	10.74	42.46
	p				001***	0.147	<.001***
6MPM	Mean (SD)	2.5 (0.91)	3.0 (1.13)	3.3 (1.25)	0.7 (1.24)	0.2 (1.36)	0.8 (1.14)
	$\beta$				0.43	0.04	0.47
	p				<.001***	0.750	<.001***
6MStop	Mean (SD)	1.0 (1.24)	0.6 (0.70)	0.4 (0.83)	−0.5 (1.29)	−0.1 (0.74)	−0.6 (1.17)
	$\beta$.				−0.59	−0.20	−0.79
	p				<.001***	0.380	<.001***

Means and graphs obtained with raw data; $\beta$ is the model estimate and p is the p-value provided by the corresponding regression model. PFWD: Pain-free treadmill walking distance (in meters); FWD: Functional treadmill walking distance (in meters); MWD: Maximal treadmill walking distance (in meters); 6 MWD: 6-Minute walk distance (in meters); 6MPM: 6-Minute pain distance (in minutes); 6MStop – 6-Minute number of stops. Significance: ^p < 0.1, *p < 0.05, **p < 0.01, ***p < 0.001. Number of participants (n) may differ in some rows. Significant (or marginally significant) values are highlighted in bold.