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. 2023 Nov 8;24(12):e56964. doi: 10.15252/embr.202356964

Figure 1. Arsenic trioxide (ATO) alone or in combination with (−)‐gossypol (Gos) effectively blocks migration of GSCs.

Figure 1

  • A–D
    Sphere migration assays of GS‐3 (A), GS‐5 (B), and GS‐8 (C) and of the primary culture 17/02 (D), treated with sublethal concentrations of ATO (2.5 μM), Gos (5 μM), or solvent (H2O and DMSO, respectively). The experiment was performed at least in three biological replicates performed in triplicate (n ≥ 9). Migration distance was measured after 0 h (false color, yellow) and 24 h (false color, blue). Scale bars: 500 μm.

Data information: In (A–D), data are presented as mean ± SEM. ns, not significant; ***P < 0.001; ****P < 0.0001; against DMSO/H2O‐treated cells (two‐way ANOVA with Tukey's multiple‐comparison test; GraphPad Prism 9).

Source data are available online for this figure.