Table 1.
Univariate analysis: comparison of ICD and nICD groups.
| ICD group (n = 33) | nICD group (n = 252) | ||
|---|---|---|---|
| Demographics characteristics | |||
| Gender (Male) | 18 (54.55%) | 112 (44.44%) | 0.273 |
| History of coffee (Yes) | 2 (6.06%) | 4 (1.59%) | 0.092 |
| History of smoking (Yes) | 5 (15.15%) | 38 (15.08%) | 0.991 |
| History of alcohol (Yes) | 6 (18.18%) | 35 (13.89%) | 0.509 |
| Age (years) | 66.0 (59.0,69.5) |
67.0 (59.0,71.0) |
0.202 |
| Education level (years) | 0.394 | ||
| 0 ~ 6 | 5 (15.15%) | 60 (23.81%) | |
| 7 ~ 9 | 13 (39.39%) | 77 (30.56%) | |
| 10 ~ 12 | 6 (18.18%) | 73 (28.67%) | |
| >12 | 9 (27.27%) | 42 (16.67%) | |
| Disease duration (years) | 8.0 (3.5,12.0) |
5.0 (2.0,7.0) |
0.001* |
| Motor symptoms | |||
| UPDRS III | 62.0 (40.0,79.0) |
48.0 (34.0,65.8) |
0.035* |
| H-Y grading | 0.213 | ||
| 1 | 3 | 45 | |
| 1.5 | 2 | 28 | |
| 2 | 13 | 83 | |
| 2.5 | 1 | 11 | |
| 3 | 14 | 74 | |
| 4 | 0 | 5 | |
| 5 | 0 | 6 | |
| Dyskinesia (Presence) | 8 (24.24%) | 28(11.11%) | 0.033* |
| Non-motor symptoms | |||
| HAMD (scores ≥21) | 14 (42.42%) | 87 (34.52%) | 0.372 |
| HAMA (scores ≥14) | 21 (63.64%) | 105 (41.67%) | 0.017* |
| AES (scores ≥14) | 26 (78.79%) | 184 (73.02%) | 0.479 |
| RBDSQ (scores ≥5) | 21 (63.64%) | 91 (36.11%) | 0.002* |
| MoCA | 22.0 (17.0,24.0) |
22.0 (17.3,25.0) |
0.743 |
| MMSE | 27.0 (25.0,28.5) |
27.0 (23.0,28.0) |
0.517 |
| Medication | |||
| LEDD | 500.0 (337.5,793.8) |
375.0 (300.0,650.0) |
0.015* |
| Dopamine receptor agonists (Yes) | 22 (66.67%) | 129 (51.19%) | 0.094 |
| Pramipexole (Yes) | 16 (48.48%) | 91 (36.11%) | 0.167 |
| Amantadine (Yes) | 9 (27.27%) | 44 (17.46%) | 0.173 |
| Selegiline (Yes) | 2 (6.06%) | 7 (2.78%) | 0.311 |
Probability presented for qualitative variables. Median and interquartile range for quantitative variables. *p < 0.05.