FIGURE 5.

Electrostatic (A) and steric (B) contour maps of the CoMFA model around molecule 22. When the peripheral part of the molecule is colored green, the activity of the molecule is enhanced by a group with a large connecting space, and when it is colored yellow, the activity of the compound could be reduced by the presence of the group with the large connecting space. The blue colored regions indicate a preference for positive groups that may lead to an increase in anti-VEGFR-2 activity, while the red colored regions indicate a preference for negative groups.