TABLE 4.
Toxicity profile of newly designed compounds.
| Compounds | AMES toxicity | Max. tolerated dose (human) | hERG I/II inhibitor | Oral rat acute toxicity (LD50) | Oral rat chronic toxicity (LOAEL) | Skin sensitization |
|---|---|---|---|---|---|---|
| Yes/No | Log mg/kg/day | Y/N | Mol/kg | Log mg/kg_ bw/day | Yes/No | |
| T01 | No | 0.552 | No/Yes | 2.648 | −1.075 | No |
| T02 | No | 0.547 | No/Yes | 2.923 | −0.985 | No |
| T03 | No | 0.534 | No/Yes | 2.625 | −0.454 | No |
| T04 | No | 0.423 | No/Yes | 2.423 | −0.041 | No |
| T05 | No | 0.285 | No/Yes | 2.488 | −0.426 | No |
| T06 | No | 0.482 | No/Yes | 2.649 | −0.843 | No |
| Molecule 22 | No | 0.603 | No/Yes | 2.729 | −0.426 | No |