TABLE 7.

MMPBSA calculations of binding free energy for all complexes.

Complex	Binding energy (kJ/mol)	SASA energy (kJ/mol)	Polar solvation energy (kJ/mol)	Electrostaticenergy (kJ/mol)	Van der Waals energy (kJ/mol)
4ASD/Foretinib	−48.084 +/- 49.845	−23.295 +/- 1.286	356.488 +/- 94.279	−187.730 +/- 84.457	−193.548 +/- 21.570
4ASD/Mol22	−34.943 +/- 37.198	−22.269 +/- 1.009	451.645 +/- 64.355	−141.591 +/- 39.791	−173.847 +/- 16.793
4ASD/T01	−59.176 +/- 40.252	−23.316 +/- 1.252	317.898 +/- 60.344	−290.472 +/- 48.945	−212.166 +/- 16.943