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. 2023 Nov 22;14:1290391. doi: 10.3389/fimmu.2023.1290391

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Copyright © 2023 Provera, Ramavath, Gadipudi, Gigliotti, Boggio, Vecchio, Stoppa, Rolla, Boldorini, Pirisi, Smirne, Albano, Dianzani and Sutti

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ICOSL deficiency reduced monocyte-derived macrophage distribution and crown-like macrophage aggregates in rodent MASH livers. Wild type (WT) and ICOSL deficient (ICOSL ko) mice were fed with either control or Western (WD) diets for 24 weeks and the animals were investigated for the distribution of hepatic macrophages. (A) Flow cytometry analysis of the distribution of Ly6C^high/CD11b^high/F4-80⁺ pro-inflammatory monocyte/macrophages (MoMFs) and CD206⁺/CD11b^low/F4-80⁺ macrophages (MPhs). (B) Immunofluorescence (IF) staining of macrophage crown-like structures (hCLSs) using anti-F4-80 antibodies (arrows). The values refer to 4 animals per group ± SD.