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. 2023 Nov 22;14:1290391. doi: 10.3389/fimmu.2023.1290391

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Copyright © 2023 Provera, Ramavath, Gadipudi, Gigliotti, Boggio, Vecchio, Stoppa, Rolla, Boldorini, Pirisi, Smirne, Albano, Dianzani and Sutti

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interference with ICOS/ICOSL dyad selectively affects the distribution of TREM2 expressing cells among MASH-associated hepatic macrophages. (A) Distribution of TREM2⁺/CD9⁺ cells among CD11b^high/F4-80⁺ monocyte/macrophages (MoMFs) and CD11b^low/F4-80⁺ macrophages (Mphs) in the liver of wild type (WT) and ICOSL deficient (ICOSL ko) fed with either control or Western (WD) diets for 24 weeks. (B) Distribution of TREM2⁺/ICOSL⁺ cells among CD11b^high/F4-80⁺ monocyte/macrophages (MoMFs) and CD11b^low/F4-80⁺ macrophages (MPhs) in the liver of wild type (WT) and ICOS deficient (ICOS ko) fed with either control or Western (WD) diets for 24 weeks. The values refer to 4 animals per group ± SD.