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. 2023 Nov 22;14:1221260. doi: 10.3389/fimmu.2023.1221260

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Copyright © 2023 Yang, Luan, Li, Niu, He, Zhao, Chen, Mao, Mou and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Single-cell landscape of circulating immune cells from PV patients and HCs. (A) Schematic flowchart of scRNA-seq experimental design of this study. (B) UMAP representation of 71,966 and 55,838 single cells from PV patients (n = 5) and HCs (n = 3), respectively, showing the formation of 10 clusters. (C) The fraction of cells for ten cell types in HCs and PV patients. (D) Bar graphs of each cell cluster population between HCs and PV patients. (E) Bubble plot of top5 gene expression in each cell cluster; the size of the bubble represents the percentage of expressed cells; the color represents the average expression of each gene in clusters: red means the high expression.