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. 2023 Nov 22;14:1221260. doi: 10.3389/fimmu.2023.1221260

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Copyright © 2023 Yang, Luan, Li, Niu, He, Zhao, Chen, Mao, Mou and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The heterogeneity and transcriptional features of NK&T cells in PV patients. (A) UMAP representation of 91,224 NK&T cells, showing the formation of nine clusters. (B) The fraction of cells for nine types in HCs and PV patients. (C) Bar graphs of each cell cluster population between HCs and PV patients. (D) Bubble plot of top5 gene expression in each cell cluster; the size of bubble represents the percentage of expressed cells; the color represents the average expression of each gene in clusters: red means the high expression. (E) GO analysis showing the biological process enriched in Treg NK and NKT of PV patients. (F) Heatmap showing the average expression of key regulatory TFs (estimated using SCENIC) between NK cells and T cell subsets in PV patients and HCs.