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. 2023 Nov 22;14:1221260. doi: 10.3389/fimmu.2023.1221260

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Copyright © 2023 Yang, Luan, Li, Niu, He, Zhao, Chen, Mao, Mou and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The heterogeneity and transcriptional features of B cells in PV patients. (A) UMAP representation of B cells, showing the formation of two clusters. (B) The fraction of cells for ten two types in HCs and PV patients. (C) Bar graphs of each cell cluster population between HCs and PV patients. (D) Bubble plot of top 5 gene expression in each cell cluster; the size of the bubble represents the percentage of expressed cells; the color represents the average expression of each gene in clusters: red means the high expression. (E) The violin diagram shows the expression levels of IGHA1, IGHA2 and IGHG1 in PV patients and HCs. (F) The mapplot of GO pathways of the DEGs in memory B cells of PV patients.