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. 2023 Nov 22;14:1221260. doi: 10.3389/fimmu.2023.1221260

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Copyright © 2023 Yang, Luan, Li, Niu, He, Zhao, Chen, Mao, Mou and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The heterogeneity and transcriptional features of monocytes in PV patients. (A) UMAP representation of monocytes, showing the formation of two clusters. (B) The fraction of cells for two types in HCs and PV patients. (C) Bubble plot of top5 gene expression in each cell cluster; the size of the bubble represents the percentage of expressed cells; the color represents the average expression of each gene in clusters: red means the high expression. (D) The violin diagram shows the expression levels of TNF, IL1B, DUSP2, S100A8, CCL3, CCL3L1, CCL4L2, CXCL, EGR1, FOS, JUN, and JUND in PV patients and HCs. (E) GO analysis showing the biological process enriched in non-classical monocytes and pDC of PV patients. (F) Heatmap showing the average expression of key regulatory TFs (estimated using SCENIC) between monocyte subsets in PV patients and HCs.