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. 2023 Nov 22;14:1221260. doi: 10.3389/fimmu.2023.1221260

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Copyright © 2023 Yang, Luan, Li, Niu, He, Zhao, Chen, Mao, Mou and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Complex intercellular communication network in the circulating immune cells in PV patients. (A) Hierarchical plot showing the inferred intercellular communication network for MIF signaling pathway. Circle sizes are proportional to the number of cells in each cell group and edge width represents the communication probability. (B) Heatmap showing the relative importance of each cell group for the four network centrality measures-based MIF signaling network. (C) Relative contribution of each ligand–receptor pair to the overall communication network of MIF signaling pathway. (D) The inferred CXCL signaling pathway network. (E) The computed network centrality measures of CXCL signaling. (F) Relative contribution of each CXCL ligand–receptor pair. (G) Analysis of CXCL8, CXCL9, CCL5 and CXCR2 mRNA expression by qPCR. Data are expressed as mean ± SEM and significance was set at *p ≤ 0.05, ***p ≤ 0.001.