Table 2.

Microvascular Complications: Rates for never versus experienced pregnancy and risk associated with pregnancy (unadjusted and adjusted)

	Rates of Complications*				Risk Assessment†
Complication	Never Pregnant	Experienced Pregnancy	p-value	Model	Never Pregnant	Experienced Pregnancy	p-value
Macroalbuminuria	22/291 (7.6)	18/116 (15.5)	0. 015	Unadjusted	Ref	1.45 (0.62 – 3.39)	0.40
				Adjusted	Ref	1.49 (0.57 – 3.89)	0.42
Microalbuminuria	102/291 (35.1)	53/116 (45.7)	0.046	Unadjusted	Ref	0.94 (0.53 – 1.68)	0.84
				Adjusted	Ref	1.17 (0.63 – 2.17)	0.62
Hyperfiltration	101/218 (46.3)	53/84 (63.1)	0.009	Unadjusted	Ref	1.82 (0.96 – 3.47)	0.07
				Adjusted	Ref	2.76 (1.38 – 5.49)	0.004
Diabetic Retinopathy	62/151 (41.1)	44/90 (48.9)	0.24	Unadjusted	Ref	1.47 (0.86 – 2.53)	0.16‡
				Adjusted	Ref	1.24 (0.61 – 2.50)	0.55‡§
Peripheral Neuropathy	47/289 (16.3)	27/116 (23.3)	0.10	Unadjusted	Ref	1.43 (0.82 – 2.52)	0.21
				Adjusted	Ref	1.34 (0.73 – 2.44)	0.35
Microvascular Disease‖	153/284 (53.9)	84/113 (74.3)	<0.001	Unadjusted	Ref	1.50 (1.01 – 2.23)	0.05
				Adjusted	Ref	1.47 (0.96 – 2.26)	0.08

^*Data shown represents n/N and (%) based on the number of participants with the data sufficient to determine whether or not the event occurred among the female participants in TODAY. Participants with missing data for outcomes are excluded.

^†Data shown represents hazard ratios and 95% confidence intervals for Cox regression models unless otherwise indicated. Models were adjusted for maternal age at baseline, race or ethnicity, household income, duration of diabetes at baseline, baseline high HbA1c (>6%), and baseline BMI.

^‡Odds ratios and 95% confidence intervals based on logistic regression models.

^§Model was adjusted for maternal age at baseline, race or ethnicity, household income, duration of diabetes at initial eye exam, baseline high HbA1c (>6%), and baseline BMI.

^‖Microvascular disease is the composite of microalbuminuria, macroalbuminuria, diabetic retinopathy, and peripheral neuropathy.

Ref – reference group for all risk assessment models is never pregnant