Figure 3.

The clinical effect of genetic diagnosis on patient management. Physician responses to 1-month post-test questionnaires were used to assess the effect of genetic test findings on patient management. (A) Frequency of physician-reported changes because of genetic testing in four management categories (treatment plan changes, discussions around family planning, referrals to genetic counseling, and referrals for testing for at-risk family members) among patients with positive genetic findings (red) and negative genetic findings (blue) P < 0.001 for comparisons between positive and negative groups, for all categories. (B) Frequency of treatment plan changes among patients with positive genetic findings (red) and negative genetic findings (blue). *P < 0.05, **P < 0.001. NS, not significant.