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. Author manuscript; available in PMC: 2023 Dec 7.
Published in final edited form as: View (Beijing). 2023 Mar 1;4(5):20220085. doi: 10.1002/VIW.20220085

Table 1.

Different nuclear medicine tracers targeting CD146

Types of cancer Radionuclides Imaging agents Tumor models References
Breast cancer 52Mn 52Mn-DOTA-YY146 MDA-MB-435 orthotopic breast cancer [76]
64Cu 64Cu-DOTA-YY146 MDA-MB-435 orthotopic breast cancer [35]
Malignant melanoma 68Ga 68Ga-Fab’2 TsCD146 C8161 xenograft melanoma [1]
89Zr 89Zr-DFO-YY146 A375 subcutaneous melanoma [69]
Brain tumor 89Zr 89Zr-DFO-YY146 U87MG subcutaneous brain tumor [81]
64Cu 64Cu-NOTA-YY146 U87MG subcutaneous brain tumor [27]
Lung cancer 64Cu 64Cu-NOTA-YY146 H460 subcutaneous lung cancer [70]
64Cu 64Cu-NOTA-YY146 H460 intrapulmonary metastasis model [83]
Hepatocellular carcinoma 89Zr 89Zr-DFO-YY146 HepG2 subcutaneous liver tumor [71]
Epithelioid mesothelioma 99mTc 99mTc-anti-CD146 scFv Mesothelioma xenograft [87]