Table 5.
Culture results of tissues in combination therapy.
| Treatments | Infection confirmation | |||
|---|---|---|---|---|
| BSK-H^ | mBSK-II^ | Combined culturesa | p-value | |
| Infected Untreated (OG) | 3/3 | ND | 3/3 | |
| Infected Untreated (IP) | 5/5 | ND | 5/5 | |
| Infected Untreated (SC) | 2/2 | ND | 2/2 | |
| Azlocillin (IP) + Bactrim (OG) | 5/5 | ND | 5/5 | 1c |
| Disulfiram (OG) + Bactrim (OG) | 5/5 | ND | 5/5 | 1b |
| Disulfiram (OG) + Azlocillin (IP) | 4/5 | 4/5 | 4/5 | 1c |
| Doxycycline (OG) + Ceftriaxone (IP) | 0/5 | 0/5 | 0/5 | 0.0008c* |
| Doxycycline (OG) + Ceftriaxone (IP) + Carbomycin (SC) | 0/5 | 0/5 | 0/5 | 0.0003e* |
| Dapsone (OG) + Rifampicin (OG) | 0/5 | 0/5 | 0/5 | 0.0179b* |
| Dapsone (OG) + Clofazimine (OG) | 0/5 | 0/5 | 0/5 | 0.0179b* |
| Dapsone (OG) + Clofazimine (OG) + Rifampicin (OG) | 0/5 | 0/5 | 0/5 | 0.0179b* |
| Cefotaxime (IP) + Loratadine (OG) + Doxycycline (OG) | 0/5 | 0/5 | 0/5 | 0.0008c* |
| Cefotaxime (IP) + Doxycycline (OG) | 0/5 | 0/5 | 0/5 | 0.0008c* |
| Cefotaxime (IP) + Carbomycin (SC) | 0/5 | 0/5 | 0/5 | 0.0013d* |
ND, not done; OG, oral gavage; IP, intraperitoneal; SC, subcutaneous. * Statistically significant. Fisher exact test, the result is significant at p < 0.05.
a
Number of mouse positive for at least one tissue/total number of mice tested.
b
Compared to OG control group.
c
Compared to OG + IP control group.
d
IP + SC control group.
e
OG + IP + SC control group.