Table 1. Genes significantly up- and down-regulated in miR-238(-).
List of genes significantly up- and down-regulated in miR-238(n4112) compared to wildtype day 5 animals. Genes with previously reported longevity phenotypes and the supporting references are indicated [34–38].
| Common Name | Sequence Name | log2 (FC) | Description | RNAi Longevity Phenotype | Longevity References |
|---|---|---|---|---|---|
| ilys-3 | C45G7.3 | 2.22 | Invertebrate LYSozyme | n/a | |
| oac-54 | W07A12.6 | 1.97 | O-ACyltransferase homolog | n/a | |
| pqn-36 | F39D8.1 | 1.89 | Prion-like-(Q/N-rich)-domain-bearing protein | n/a | |
| clec-82 | Y54G2A.8 | 1.84 | C-type LECtin | n/a | |
| gsa-1 | R06A10.2 | 1.69 | G protein, Subunit Alpha | shortened life span | Xue H et al., 2007 |
| zip-8 | F23F12.9 | 1.64 | bZIP transcription factor family | n/a | |
| gtl-1 | C05C12.3 | 1.57 | Gon-Two Like (TRP subfamily) | n/a | |
| myo-5 | F58G4.1 | 1.50 | MYOsin heavy chain structural genes | n/a | |
| kin-36 | T22B11.4 | 1.38 | protein KINase | n/a | |
| T10D4.6 | 1.35 | n/a | dauer lifespan extended in daf-2(e1370); aak-1(tm1944); aak-2(ok524) background | Xie M & Roy R, 2012 | |
| tag-273 | Y57G11A.1 | 1.29 | n/a | n/a | |
| acs-2 | F28F8.2 | 1.27 | fatty Acid CoA Synthetase family | n/a | |
| cht-1 | C04F6.3 | 1.23 | CHiTinase | n/a | |
| Y105C5B.3 | 1.22 | n/a | n/a | ||
| F56D5.6 | 1.22 | n/a | n/a | ||
| lec-2 | F52H3.7 | 1.19 | gaLECtin | n/a | |
| oac-14 | F09B9.1 | 1.19 | O-ACyltransferase homolog | n/a | |
| clik-2 | C53C9.2 | 1.13 | CaLponIn-liKe proteins | n/a | |
| cest-12 | Y75B8A.3 | 1.12 | Carboxyl ESTerase domain containin | n/a | |
| nmy-1 | F52B10.1 | 1.12 | Non-muscle MYosin | n/a | |
| C50F7.5 | 1.07 | n/a | n/a | ||
| T14G8.3 | 1.04 | n/a | n/a | ||
| pqn-31 | F21C10.8 | 1.02 | Prion-like-(Q/N-rich)-domain-bearing protein | n/a | |
| acp-5 | F13D11.1 | 1.01 | ACid Phosphatase family | n/a | |
| hil-3 | F22F1.1 | 0.95 | HIstone H1 Like | n/a | |
| ZK380.6 | -2.23 | n/a | |||
| ZC317.7 | -2.13 | n/a | |||
| C36C9.10 | -2.04 | n/a | |||
| grd-4 | T01B10.1 | -1.93 | groundhog (hedgehog-like family) | n/a | |
| Y40A1A.6 | -1.82 | n/a | |||
| C06A5.12 | -1.82 | n/a | |||
| irg-4 | F08G5.6 | -1.57 | Infection Response Gene | n/a | |
| Y73F8A.1173 | -1.53 | n/a | |||
| B0511.11 | -1.51 | n/a | |||
| F57A10.4 | -1.49 | n/a | |||
| clec-52 | B0218.8 | -1.46 | C-type LECtin | n/a | |
| acbp-6 | Y17G7B.1 | -1.46 | Acyl-Coenzyme A Binding Protein | dauer lifespan extended | Xie M & Roy R, 2012 |
| spp-12 | T22G5.7 | -1.45 | SaPosin-like Protein family | shortened lifespan in fer-15(b26);daf-2(mu150);fem-1(hc17) background | Murphy CT et al., 2003 |
| F23D12.11 | -1.45 | n/a | |||
| impt-1 | Y52B11A.2 | -1.42 | MPacT rwd (RWD) domain containing homolog | extended lifespan | Ferraz RC et al., 2016 |
| tag-51 | K02F3.1 | -1.40 | n/a | ||
| C10B5.1 | -1.39 | n/a | |||
| clec-47 | T09F5.9 | -1.39 | C-type LECtin | n/a | |
| ugtp-1 | ZK370.7 | -1.35 | UDP-Galactose Transporter Protein family | n/a | |
| C06H5.14 | -1.35 | n/a | |||
| clec-3 | C41H7.7 | -1.33 | C-type LECtin | n/a | |
| EEED8.13 | -1.28 | n/a | |||
| T16H12.2 | -1.27 | n/a | |||
| C16A3.2 | -1.27 | n/a | |||
| T28A11.2 | -1.27 | n/a | |||
| F54D5.4 | -1.26 | n/a | |||
| C23H5.8 | -1.24 | n/a | |||
| D1086.3 | -1.22 | n/a | |||
| crn-5 | C14A4.5 | -1.13 | Cell-death-Related Nuclease | extended lifespan in eri-1(mg366) background | Curran SP & Ruvkun G, 2007 |
| K08D8.5 | -1.13 | n/a | |||
| phip-1 | F36A2.8 | -1.12 | Protein HIstidine Phosphatase | n/a | |
| C17G10.13 | -1.11 | n/a | |||
| mff-2 | F55F8.6 | -1.07 | Mitochondrial Fission Factor | n/a | |
| ZC412.3 | -1.05 | n/a | |||
| tpk-1 | ZK637.9 | -1.03 | Thiamine PyrophosphoKinase | n/a | |
| ZK643.2 | -1.03 | n/a | |||
| cup-15 | F42A8.3 | -1.02 | Coelomocyte UPtake-defective | n/a | |
| bath-27 | F14D2.1 | -1.02 | BTB and MATH domain containing | n/a | |
| adbp-1 | VW02B12L.4 | -1.00 | ADR-2 Binding Protein | n/a | |
| lmd-1 | F43G9.2 | -1.00 | LysM Domain (peptidoglycan binding) protein | n/a | |
| R04F11.5 | -0.98 | n/a | |||
| B0304.4 | -0.97 | n/a | |||
| EEED8.14 | -0.95 | n/a | |||
| C35E7.8 | -0.92 | n/a |