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. 2023 Nov 20;14:1275136. doi: 10.3389/fimmu.2023.1275136

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Copyright © 2023 Knoll, Bonaguro, dos Santos, Warnat-Herresthal, Jacobs-Cleophas, Blümel, Reusch, Horne, Herbert, Nuesch-Germano, Otten, van der Heijden, van de Wijer, Shalek, Händler, Becker, Beyer, Netea, Joosten, van der Ven, Schultze and Aschenbrenner

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Bulk transcriptomics of monocytes in PLHIV mainly reveals IFN-signaling (A) Volcano plot showing the DEGs (adj. p.val<0.05, |FC|>1.5) in HIV vs. control of bulk CD14⁺ monocyte transcriptomes. (B) Boxplot and whisker of selected HIV-specific genes. Wilcoxon rank-sum for statistical testing (*: p-value <0.05, **: p-value <0.01). (C) Functional enrichment using the GO and Hallmark databases upregulated DEG (HIV vs Ctrl). (D) Intersecting DEG for the comparison of HIV vs Ctrl in bulk transcriptomes from CD14⁺ monocytes and PBMCs. Commonly upregulated DEG mapped to PBMC clusters from Figure 1C.