Table 1.
| WHO category | Resistant genes | Anti-TB drug or drug class |
|---|---|---|
| First-line agents | rpoB | Rifampicin |
| ponA1 | ||
| katG | Rifampicin | |
| Isoniazid | ||
| inhA | Ethionamide | |
| Isoniazid | ||
| oxyR-ahpC | ||
| dfrA | ||
| ahpC | ||
| kasA | ||
| furA-katG | ||
| pncA | Pyrazinamide | |
| panD | ||
| rpsA | ||
| embCAB operon | Ethambutol | |
| ubiA | ||
|
| ||
| Group A | gyrA/B | Fluoroquinolones |
| atpE | Bedaquiline | |
| pepQ | ||
| Rev0778 | ||
| Rrl | Linezolid | |
| rplC | ||
|
| ||
| Group B | Rv0678 | BRD-9327 |
| Rv0678 | Clofazimine | |
| pepQ | ||
| Rv1979 | ||
| Rv2535c | ||
| ndh | ||
| Ald | Cycloserine, terizidone | |
| alr | ||
| ddl | ||
| cycA | ||
|
| ||
| Group C | ddn | Delamanid, pretomanid |
| fgd1 | ||
| fbiA/B/C | ||
| crfA | Imipenem/cilastatin | |
| rrs | Streptomycin | |
| rpsl | ||
| rrs | ||
| gidB | ||
|
| ||
| Group C | ethA | Ethionamide, prothionamide |
| ethR | ||
| mshA | ||
| ndh | ||
| inhA | ||
| folC | Para-aminosalicyclic acid (PAS) | |
| dfrA | ||
| thyA/X | ||
| ribD | ||
|
| ||
| Other medicines | Eis | Kanamycin |
| tlyA | Capreomycin | |
| rrl | Aminoglycosides | |
| embB | Ethambutol | |