Table 2. Associations of combined family history and genetic and lifestyle risk with diabetes.
| DM/number of participants | % | OR, 95%CI | ||||
|---|---|---|---|---|---|---|
| Family history, no | Low genetic risk | Ideal (＜1 poor factors) | 34/1578 | (2.2) | Ref | |
| Intermediate (2 poor factors) | 15/541 | (2.8) | 1.19 | (0.62-2.19) | ||
| Poor (＞3 poor factors) | 16/184 | (8.7) | 3.73 | (1.92-7.00) | ||
| Intermediate genetic risk | Ideal (＜1 poor factors) | 64/1499 | (4.3) | 2.10 | (1.38-3.25) | |
| Intermediate (2 poor factors) | 28/541 | (5.2) | 2.81 | (1.65-4.74) | ||
| Poor (＞3 poor factors) | 15/214 | (7.0) | 3.61 | (1.83-6.83) | ||
| High genetic risk | Ideal (＜1 poor factors) | 70/1419 | (4.9) | 2.49 | (1.65-3.85) | |
| Intermediate (2 poor factors) | 54/570 | (9.5) | 5.21 | (3.31-8.29) | ||
| Poor (＞3 poor factors) | 23/207 | (11.1) | 6.19 | (3.42-11.03) | ||
| Family history, yes | Low genetic risk | Ideal (＜1 poor factors) | 12/193 | (6.2) | 3.58 | (1.73-6.98) |
| Intermediate (2 poor factors) | 4/65 | (6.2) | 4.27 | (1.22-11.49) | ||
| Poor (＞3 poor factors) | 5/21 | (23.8) | 12.01 | (3.43-36.90) | ||
| Intermediate genetic risk | Ideal (＜1 poor factors) | 19/206 | (9.2) | 6.02 | (3.25-10.85) | |
| Intermediate (2 poor factors) | 14/90 | (15.6) | 11.25 | (5.45-22.31) | ||
| Poor (＞3 poor factors) | 10/31 | (32.3) | 34.83 | (13.74-85.27) | ||
| High genetic risk | Ideal (＜1 poor factors) | 53/240 | (22.1) | 16.99 | (10.59-27.60) | |
| Intermediate (2 poor factors) | 24/107 | (22.4) | 17.82 | (9.68-32.51) | ||
| Poor (＞3 poor factors) | 7/39 | (17.9) | 12.00 | (4.34-29.97) |
Abbreviations: CI, confidence interval; DM, diabetes mellitus; OR, odds ratio.
Adjusted for age, sex and first six principal components.