Supplemental Table 6. Associations of family history, PRS, and lifestyle risk with diabetes prevalence among participants over 60 years old.
| DM/number of participants | % | OR, 95%CI | ||||
|---|---|---|---|---|---|---|
| Family history, no | Low genetic risk | Ideal (＜1 poor factors) | 31/862 | (3.6) | Ref | |
| Intermediate (2 poor factors) | 12/264 | (4.5) | 1.08 | (0.52-2.11) | ||
| Poor (＞3 poor factors) | 8/99 | (8.1) | 1.95 | (0.80-4.26) | ||
| Intermediate genetic risk | Ideal (＜1 poor factors) | 59/836 | (7.1) | 2.11 | (1.36-3.35) | |
| Intermediate (2 poor factors) | 22/251 | (8.8) | 2.5 | (1.39-4.42) | ||
| Poor (＞3 poor factors) | 12/90 | (13.3) | 3.58 | (1.67-7.24) | ||
| High genetic risk | Ideal (＜1 poor factors) | 65/808 | (8.0) | 2.5 | (1.62-3.93) | |
| Intermediate (2 poor factors) | 44/275 | (16.0) | 4.77 | (2.92-7.86) | ||
| Poor (＞3 poor factors) | 16/89 | (18.0) | 5.15 | (2.59-9.95) | ||
| Family history, yes | Low genetic risk | Ideal (＜1 poor factors) | 9/99 | (9.1) | 2.99 | (1.30-6.28) |
| Intermediate (2 poor factors) | 3/25 | (12.0) | 3.99 | (0.91-12.46) | ||
| Poor (＞3 poor factors) | 5/11 | (45.5) | 15.99 | (4.24-58.17) | ||
| Intermediate genetic risk | Ideal (＜1 poor factors) | 17/108 | (15.7) | 6.02 | (3.12-11.30) | |
| Intermediate (2 poor factors) | 10/41 | (24.4) | 9.18 | (3.92-20.22) | ||
| Poor (＞3 poor factors) | 6/13 | (46.2) | 23.93 | (7.20-77.52) | ||
| High genetic risk | Ideal (＜1 poor factors) | 48/125 | (38.4) | 19.6 | (11.73-33.23) | |
| Intermediate (2 poor factors) | 17/47 | (36.2) | 15.73 | (7.65-31.95) | ||
| Poor (＞3 poor factors) | 5/17 | (29.4) | 9.83 | (2.92-29.05) |
Abbreviations: PRS, polygenic risk score; CI, confidence interval; DM, diabetes mellitus; OR, odds ratio.
Analysis by multivariable logistic regression model.
Adjusted for age, sex and first 6 principal components.