Supplemental Table 7. Area under the receiver operating characteristic curve for genetic and lifestyle risk to predict diabetes according to median age.
| ＜60 years old | ≥ 60 years old | |
|---|---|---|
| Area under the receiver operating characteristic curve (95% CI) | ||
| Model 1 a | 0.766 (0.714-0.817) | 0.616 (0.587-0.645) |
| Model 1 + PRS | 0.775 (0.722-0.828) | 0.672 (0.644-0.700) |
| Model 1 + lifestyle score | 0.792 (0.743-0.841) | 0.635 (0.607-0.663) |
| Model 1 + family history | 0.807 (0.762-0.852) | 0.688 (0.660-0.717) |
| Model 1 + PRS + lifestyle score | 0.801 (0.752-0.851) | 0.683 (0.656-0.710) |
| Model 1 + PRS + family history | 0.810 (0.764-0.857) | 0.720 (0.693-0.748) |
| Model 1 + lifestyle + family history | 0.829 (0.783-0.875) | 0.701 (0.674-0.729) |
| Model 1 + PRS + lifestyle + family history | 0.831 (0.784-0.877) | 0.729 (0.702-0.757) |
Abbreviations: CI, confidence interval; PRS, polygenic risk score.
a Model 1 was adjusted for age, sex, and the top six principal components.
Diabetes: defined as non-fasting glucose ≥ 200 mg/dL, hemoglobin A1c ≥ 6.5, and/or self-reported treatment for diabetes.