Supplemental Table 8. Associations of family history, PRS, and lifestyle risk with diabetes prevalence among non-obesity.
| DM/number of participants | % | OR, 95%CI | ||||
|---|---|---|---|---|---|---|
| Family history, no | Low genetic risk | Ideal (＜1 poor factors) | 30/1446 | (2.1) | Ref | |
| Intermediate (2 poor factors) | 3/41 | (19.5) | 0.95 | (0.39-2.05) | ||
| Poor (＞3 poor factors) | 3/48 | (6.3) | 2.19 | (0.50-6.80) | ||
| Intermediate genetic risk | Ideal (＜1 poor factors) | 56/1386 | (4.0) | 2.12 | (1.35-3.40) | |
| Intermediate (2 poor factors) | 12/319 | (3.8) | 2.21 | (1.05-4.39) | ||
| Poor (＞3 poor factors) | 3/47 | (6.4) | 2.18 | (0.48-6.98) | ||
| High genetic risk | Ideal (＜1 poor factors) | 61/1307 | (4.7) | 2.53 | (1.62-4.04) | |
| Intermediate (2 poor factors) | 18/329 | (5.5) | 2.78 | (1.46-5.18) | ||
| Poor (＞3 poor factors) | 5/456 | (1.1) | 4.92 | (1.53-13.31) | ||
| Family history, yes | Low genetic risk | Ideal (＜1 poor factors) | 10/182 | (5.5) | 3.68 | (1.65-7.62) |
| Intermediate (2 poor factors) | 2/39 | (5.1) | 3.63 | (0.56-13.59) | ||
| Poor (＞3 poor factors) | 0/5 | (0.0) | 0.00 | (0.00-0.00) | ||
| Intermediate genetic risk | Ideal (＜1 poor factors) | 17/183 | (9.3) | 6.91 | (3.56-1306) | |
| Intermediate (2 poor factors) | 5/41 | (12.2) | 12.85 | (3.93-35.63) | ||
| Poor (＞3 poor factors) | 0/5 | (0.0) | 0.00 | (0.00-0.00) | ||
| High genetic risk | Ideal (＜1 poor factors) | 47/218 | (21.6) | 19.66 | (11.74-33.41) | |
| Intermediate (2 poor factors) | 8/65 | (12.3) | 8.59 | (3.30-20.42) | ||
| Poor (＞3 poor factors) | 1/12 | (8.3) | 4.51 | (0.23-29.18) |
Abbreviations: PRS, polygenic risk score; CI, confidence interval; DM, diabetes mellitus; OR, odds ratio.
Analysis by multivariable logistic regression model.
Adjusted for age, sex and first 6 principal components.