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Anti-inflammatory mechanism of Caffeic acid. Many modulators involve inflammation to tumor progression, including NF-kB, COX-2, TNF-a, IL-6, Nrf2, iNOS, NFAT, and HIF-1α. Caffeic acid is an agent that target NF-κB and COX-2. This can suppress cancer angiogenesis. The role of Caffeic acid is illustrated in Fig. 3 [73].
