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1,8-cineole is metabolized to its metabolites by cytochrome P450. Microsomal investigations have shown that P450 enzymes are involved in cineole metabolism. The predominant metabolite in liver microsomes is 2 -hydroxycineole, but 3 -hydroxycineole has also been detected in human microsomes. Both investigations discovered that CYP3A enzymes catalyzed cineole oxidation.
