Fig. 7.

Anticancer mechanism of action of Linalool which represent inhibition of angiogenic activity of endothelial cells by downregulating intracellular ATP levels and activating TRPM8. Linalool stimulates the transient receptor potential cation channel subfamily M (melastatin) member (TRPM) and enhances the activation of extracellular signal-regulated kinase (ERK)8. Furthermore, ATP totally reverses linalool-induced ERK phosphorylation. Furthermore, ERK activation produced by linalool inhibits the production of bone morphogenetic protein (BMP)-2. These data suggest that linalool has an anti-angiogenic impact, which is mediated via lowering intracellular ATP levels and activating TRPM8.