Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Nov 20;20(12):2011–2020. doi: 10.1038/s41592-023-02059-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — a, SegCLR embeddings projected to 3D UMAP space, with two selected axes displayed. Each point represents an embedding (aggregation distance 50 μm) sampled from only the dendrites of mouse layer 5 pyramidal cells. The UMAP data separate into three main clusters. b, Renderings of selected cells, colored to match a for locations for which the nearest embedding fell within cluster 1 (blue) or cluster 2 (red). Projections falling within cluster 1 are strongly associated with the apical dendrite subcompartment, while cluster 2 is strongly associated with a subset of basal dendrites corresponding to cells with a distinct ‘near-projecting’ (NP) morphology (inset). c, Of the cells for which the projections fall within cluster 3, a subset have distinctive axon trajectories consistent with their axons joining a major output tract (left). These ‘tract’ cells also occupy a distinct subregion within cluster 3 (middle, green). Cells occupying the remainder of cluster 3 (middle, purple) consistently lack the axon tract morphology (right). The tract and no-tract groups are also able to be separated in both primary visual area V1 (left group of cells for both tract and no-tract) and higher visual areas (right group of cells for both tract and no-tract). Scale bars, 100 μm.