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. 2023 Dec 5;20(12):2034–2047. doi: 10.1038/s41592-023-02080-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — a, Organoids from 6 different cell lines (3 embryonic and 3 induced PSCs) treated with striatal patterning on day 10 and day 23 (one batch per cell line). b, Immunohistochemistry of day 33 striatal organoids for the LGE marker GSX2. c, Quantification of GSX2⁺ rosettes as percentage of all neural rosettes of individual organoids of 6 different cell lines on day 33. n = 4|4|5|5|5|5 organoids of one batch per cell line. d, 5 out of 6 cell lines robustly produce DARPP32⁺ neurons which co-localize with immunolabeling of GABA in day 80 organoids (cell line 178-5 being broadly negative). e, Quantification of DARPP32⁺ tissue as percentage of DAPI positive area of 6 different cell lines on day 80. n = 5|4|6|6|6|6 organoids of one batch per cell line. f, Clusters of DARPP32-positive neurons co-express the marker FOXP1 in all cell lines in day 80 organoids (n = 6 cell lines of one batch). Data shown as mean ± SD.

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