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. 2023 Nov 20;55(12):2082–2093. doi: 10.1038/s41588-023-01559-9

Fig. 6. Phenome-wide PRS pleiotropy quantifies nonspecificity.

Fig. 6

PRS pleiotropy spectra across the depression-relevant phenome, defined as the ratio of PRS prediction accuracy for secondary traits relative to LifetimeMDD (PRS pleiotropy = R2secondary/R2LifetimeMDD). a, PRSs derived from GWAS on shallow MDD phenotypes (GPpsy or 23andMe) are less specific to LifetimeMDD than the PRS derived from the GWASs on LifetimeMDD. b, MTAG-based PRSs range from highly specific (MTAG.FamilyHistory) to less specific (MTAG.Envs) compared to PRSs derived from shallow MDD phenotypes. c, SoftImpute PRSs are more specific than PRSs derived from shallow MDD phenotypes, while AutoComplete PRSs are similar. Note that GPpsy and LifetimeMDD are each used in two ways: (1) to build the PRS and (2) to evaluate PRS pleiotropy.