Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Nov 6;55(12):2149–2159. doi: 10.1038/s41588-023-01555-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — a, Locus zoom of CH GWAS results at TCL1A. b, Cis-pQTL analysis of variants affecting plasma protein levels of TCL1A in 47,133 UKB participants. c, As b, but from 35,559 ISL participants. d, RNA-seq cis-eQTL analysis of TCL1A in whole blood. e, Colocalization analysis of CH GWAS and blood eQTL signals at the TCL1A locus. The CH GWAS (green) and unadjusted eQTL signals (red) do not coincide. However, when the eQTL signal is adjusted for the 4% MAF rs78986913 variant (P_adj values shown in blue), then the peaks overlap with a PP.H4 = 85% probability that they correspond to the same signal. The position of the CH GWAS sentinel variant rs2887399 is indicated by the gray vertical line. f, TCL1A eQTL from 758 B cell RNA samples. g, TCL1A eQTL from 884 monocyte samples. In all panels except e, the r² focus is on rs2887399.