Table 1.

Associations between clonal hematopoiesis and disease in UKB

Phenotype UKB	n cases	n controls	ORa	P valuea	ORadj smokingb	Padj smokingb
C91 lymphoid leukemia	268	124,500	10.44	1.59 × 10−64	10.62	6.51 × 10−62
C911 chronic lymphocytic leukemia	229	124,010	11.94	2.59 × 10−63	12.25	9.27 × 10−61
Myeloproliferative neoplasms	194	124,670	7.62	1.60 × 10−34	7.92	1.40 × 10−34
C92 myeloid leukemia	182	124,057	7.60	1.05 × 10−33	7.41	3.85 × 10−31
F10 mental and behavioral disorders due to use of alcohol	3,069	121,730	1.91	6.32 × 10−28	1.58	9.53 × 10−14
D46 myelodysplastic syndromes	141	124,098	6.40	7.12 × 10−23	6.47	1.31 × 10−21
D473 essential hemorrhagic thrombocythaemia	183	124,056	5.32	7.71 × 10−21	5.23	9.48 × 10−20
J44 other chronic obstructive pulmonary disease	4,113	120,751	1.51	2.01 × 10−19	1.12	0.018
D45 polycythemia vera	92	124,676	8.28	1.05 × 10−18	8.12	3.29 × 10−18
C34 malignant neoplasm of bronchus and lung	1,377	123,391	1.90	2.29 × 10−18	1.45	1.00 × 10−6
C93 monocytic leukemia	25	123,134	46.51	1.01 × 10−16	47.72	9.37 × 10−17
Peripheral artery disease	2,012	122,787	1.60	9.23 × 10−14	1.27	2.46 × 10−4
D619 aplastic anemia	284	123,955	2.69	1.28 × 10−10	2.38	1.00 × 10−7
D474 osteomyelofibrosis	26	123,133	13.56	9.08 × 10−10	14.61	4.71 × 10−9
J43 emphysema	1,025	123,774	1.70	1.01 × 10−9	1.18	0.066
C83 diffuse non-Hodgkins lymphoma	359	124,536	2.29	2.73 × 10−9	2.23	3.52 × 10−8
K709 alcoholic liver disease	276	124,492	2.40	4.70 × 10−6	1.93	6.20 × 10−4
I50 heart failurec	2,922	121,942	1.28	5.03 × 10−6	1.17	0.0045

The Bonferroni cutoff level is 5.00 × 10⁻⁶, unadjusted.

Phenotype list is edited to remove redundancies and subphenotypes.

^aMultivariable regression, adjusted for sex and age at blood draw (linear and quadratic).

^bAdditionally, adjusted for smoking status (current, previous), pack years and years since stopped smoking.

^cHeart failure was included in the UKB table because prior literature reports implicated an association with CH.