Table 2.

Time-to-event analysis of three models of CH for cardiovascular disease endpoints^a

Characteristics	Barcode-CH			CPLD-CHb			CHIPc
	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value
Clonal hematopoiesis	1.01	(0.94, 1.08)	0.88	1.01	(0.90, 1.13)	0.89	1.01	(0.88, 1.15)	0.92
Age at blood draw	1.08	(1.06, 1.10)	<2 × 10−16	1.08	(1.06, 1.10)	<2 × 10−16	1.08	(1.06, 1.10)	<2 × 10−16
Previous smoking	1.15	(1.10, 1.22)	8.60 × 10−8	1.16	(1.10, 1.22)	8.20 × 10−8	1.16	(1.10, 1.22)	8.20 × 10−8
Current smoking	2.10	(1.95, 2.27)	<2 × 10−16	2.10	(1.95, 2.27)	<2 × 10−16	2.10	(1.95, 2.27)	<2 × 10−16
Hypertension	1.44	(1.37, 1.51)	<2 × 10−16	1.44	(1.37, 1.51)	<2 × 10−16	1.44	(1.37, 1.51)	<2 × 10−16
BMI	1.05	(1.04, 1.05)	<2 × 10−16	1.05	(1.04, 1.05)	<2 × 10−16	1.05	(1.04, 1.05)	<2 × 10−16

n = 118,673; number of events = 7,242; stratified by age bin and sex.

^aData are from UKB.

^bCH containing a CPLD mutation, defined using our in-house methodology (Methods).

^cCHIP is defined using the strategy described in ref. ²⁰.

CI, confidence interval from Cox regression.