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. 2023 Nov 9;55(12):2189–2199. doi: 10.1038/s41588-023-01551-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — Relative expression of MYC (a-b), and OTX2 (c-d), measured by qPCR (2^−ΔΔCt), in D458 and D283 cell lines upon CRISPRi targeting of an accessible locus within a known MYC superenhancer which promotes D458 proliferation (see also Fig. 4h). sgNT: nontargeting control; sgMYC-SE-A-C: sgRNAs targeting the MYC enhancer at D458_peak_30782, positions chr8:127330655, chr8:127330840, and chr8:127330927 (hg38) respectively. qPCR was performed on all guides in triplicate; each technical replicate is shown. Bars represent median +/− 95% CI. ** adjusted p = 0.002; *** adjusted p = 0.0008; one-sided nested ANOVA with Dunnett’s correction.