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. 2023 Nov 9;55(12):2189–2199. doi: 10.1038/s41588-023-01551-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — Forest plots of β coefficients (log hazard ratios) of Cox Proportional Hazards models fitted on n = 322 patients using L2 ridge regression to control instability due to collinearity. WNT subgroup patients were excluded due to perfect separation. Log hazard estimates are relative to Group 4 and female patients. Log hazard ratios for (a) OS and (b) PFS of Cox models including age, sex, subgroup, ecDNA and TP53 mutation as covariates. Data are presented as maximum a posteriori (MAP) estimate with a Gaussian prior (L2 regularization) +/− 95% confidence intervals.