Table 2.

Variables selected in the final model and association with 6-year lung cancer risk: multivariate logistic regression analysis.

	OR with 95% CI- SAIL (development cohort), N = 574,196	OR with 95% CI-UK Biobank (validation cohort), N = 137,918
Age-continuous	1.07 (1.06–1.08)	1.06 (1.04–1.09)
Sex—male	1.09 (1.03–1.15)	1.24 (1.04–1.48)
Socioeconomic status
SE Quintile 1 least deprived	Reference	Reference
SE Quintile 2	1.14 (1.03–1.25)	1.16 (0.83–1.63)
SE Quintile 3	1.27 (1.17–1.40)	1.24 (0.89–1.73)
SE Quintile 4	1.39 (1.27–1.51)	1.94 (1.44–2.65)
SE Quintile 5 most deprived	1.48 (1.36–1.62)	2.51 (1.88–3.39)
Family history of lung cancer	1.84 (1.38–2.38)	1.66 (1.35–2.01)
Smoking status
Never smoked	Reference	Reference
Previous smoker	3.86 (3.49–4.28)	1.52 (0.38–6.06)
Current smoker	9.94 (9.08–10.89)	9.17 (2.66–31.40)
Body mass index (BMI)-continuous	1.02 (1.01–1.03)
Presence of LTCs
Alcohol misuse	1.31 (1.14–1.48)	1.44 (0.84–2.35)
Coronary heart disease	1.12 (1.02–1.21)	0.97 (0.69–1.32)
Chronic obstructive pulmonary disease	2.01 (1.89–2.13)	2.53 (1.96–3.23)
History of previous cancer	1.37 (1.26–1.47)	1.40 (1.07–1.81)
Peripheral vascular disease	1.27 (1.16–1.38)	1.71 (1.23–2.32)
Dementia	0.40 (0.22–0.65)	No output*
Painful condition	1.14 (1.07–1.21)	1.34 (1.09–1.63)
Hypertension	0.91 (0.85–0.95)	1.25 (1.04–1.50)
Stroke/transient Ischaemic attack	1.18 (1.06–1.30)	1.41 (0.94–2.04)
History of previous pneumonia	1.38 (0.73–1.23)	0.71 (0.30–1.39)
BMI: Previous smoker interaction	0.99 (0.98–0.99)	0.98 (0.94–1.03)
BMI: Current smoker interaction	0.98 (0.97–0.99)	0.96 (0.92–1.01)

SAIL secure anonymised information linkage, OR odds ratio, CI confidence intervals.

WIMD and Townsend score were area-based measures of socioeconomic status in SAIL and UK Biobank, respectively. *No lung cancer cases were recorded in participants with dementia in the UK Biobank cohort.