Table 2.

TXNIP regulatory signaling pathways.

Signaling pathways	Classification	Regulators
Common regulatory pathway	Transcriptional factors	MondoA[36], ChREBP [37], MLX [33], FoxO1 [37, 219], Max [220], KLF6 [221], STAT3 [39], NRF2 [222], NFATC2 [212], PAX5 [118], LKZF1 [118]
	microRNAs and circular RNAs	miR-21a [40], miR-148a [41], miR-135b-5p [42], miR-152-5p [43], miR-204 [24], miR-211 [223], miR-224 [224], miR-373 [225], miR-411-5p [226], miR-17 [55], miR-452 [213], miR-20a [213], miR-128-3p [132], miR-27a-3p [87], miR-424-5p [227], CircECE1 [120], circDCUN1D4 [228]
	epigenetic regulators	EZH2 [44], UHRF1 [12]
	regulators of mRNA and protein stability	LncRNA Gm15441 [45], LncRNA SNHG15 [46]
Oncogenes and TSGs	Oncogene	C-MYC [48], K-RAS [49], Ras [50], HER2 [51]
	Tumor suppressor	P53 [27], PTEN [28]
ER stress signaling	IRE-1a branch	IRE-1a [31, 54], XBP1 [56]
	PERK branch	PERK [57], ATF4 [229], CHOP [230]
Cytokines and Growth factors	Cytokines	TNFα [59], IL-1β [61], TGFβ1 [62]
	Growth factors	IGF1 [60]
Other regulatory conditions	Hypoxia condition	HIF-1a [65]
	mitochondrial labile iron dysfunction	CISD2 [68]
	Drug treatment	All-trans retinoic acid [69]