TABLE 3.
Recombinant N. meningitidis M1080 MutY activity on substrates containing different DNA damagesa
| Substrate tested | DNA damage category | Activity |
|---|---|---|
| A:8oxoG | Mismatch (MutY) | + |
| A:C | Mismatch (Mismatch repair, MutY) | (+) |
| 8oxoG:C | Oxidized pyrimidine (Fpg) | − |
| AP substrate | AP site (AP lyase/endonuclease) | − |
| FAPY substrate | Oxidized pyrimidine (Fpg) | − |
| MNU substrate | Alkylated substrate (AlkA) | − |
a
The DNA repair proteins known to act on the different substrates are reported in brackets. +, high efficiency on a substrate; (+), low efficiency on a substrate; −, complete lack of activity on a substrate.