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. 2023 Nov 29;37(12):1081–1097. doi: 10.1007/s40263-023-01041-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 4 — Volunteer disposition for study 1402-0002. *One volunteer in the 25 mg and one volunteer in the BI 1358894 50 mg dose group prematurely discontinued the trial medication due to an adverse event. MDZ midazolam