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. 2005 Apr 1;115(4):870–878. doi: 10.1172/JCI21386

Figure 4.

Figure 4

Rabbit IgG specific to type VII collagen binds to the basement membrane and fixes complement in vivo. IF microscopy, performed on frozen sections of a perilesional mouse skin biopsy (A and B) and murine esophagus (D) reveals linear deposition of rabbit IgG (A and D) and murine C3 (B) at the basement membrane in a diseased mouse. (C) IF analysis of lesional skin from a diseased mouse shows rabbit IgG deposits on both epidermal and dermal sides of the cleavage. No deposits of rabbit IgG (E) or murine C3 (F) are detected at the DEJ of a mouse injected with control rabbit IgG (magnification, ×250).

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