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. 2005 Apr 1;115(4):870–878. doi: 10.1172/JCI21386

Figure 9.

Figure 9

C5-deficient mice are resistant to the induction of cutaneous disease by antibodies specific to type VII collagen. Erosions on back and leg and, upon tangential pressure, epidermal detachment on the ear in a C5-sufficient (A and C) but not in a C5-deficient (B and D) mouse. Mice received 5 injections, each containing 15 mg of IgG from immune rabbit serum, over a period of 10 days. Histologic analysis of murine skin revealed subepidermal cleavage and a neutrophil-rich inflammatory infiltrate in C5-sufficient mice (E) but no histological changes in C5-deficient mice (F) (magnification, ×200). IF analysis of mouse skin showed deposition of rabbit IgG in mice both deficient (G) and sufficient (H) in C5. Deposits of membrane attack complex along the dermal-epidermal junction were only observed in C5-sufficient (I) and not in C5-deficient (J) mice (magnification, ×400).

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